In September 1925, SAC was first established as University Junior College under the administration of the University of Texas. Later it was renamed as San Antonio Junior College. And finally in 1948 college was renamed in San Antonio College. Also the same year SAC was moved to its present location on San Pedro Avenue. Accreditation was granted to the college in 1955 from the Southern Association of Colleges and Schools.

SAC is the oldest public two-year college in Texas. The college has an average semester enrollment of 21,000 credit students and an average annual enrollment of 16,000 other-than-credit students. San Antonio College is the largest single-campus community college in Texas and one of the largest in the United States.

SAC provides academic, vocational and professional education that allow students to pursue their education at a university or a four-year college. It offers more than 60 different associate degrees and over 65 certificate programs. SAC is a comprehensive community college that also provides offerings in occupational and technical courses and has assumed the San Antonio Independent School District’s continuing education programs. Many students concentrating in nursing and emergency medicine, design, family and social work, law, office and administration, funeral and mortuary science, and security and law enforcement.